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Sedentary individuals have irisin levels around 3.6 ng/mL, which rise significantly to 4.3 ng/mL after aerobic interval training (Table 1, numerous human and animal studies have demonstrated that exercise increases irisin levels in the bloodstream and hippocampus and elevates FNDC5 mRNA and protein expression in muscle tissue (Pang et al., 2018

Supported by progress in targeted delivery systems, these multifaceted mechanisms underscore its significant potential for clinical application (80)

J Neuroimmunol 169:161171

Kumar P, Liu C, Hsu JW, et al

Skipping days produces skipped results