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doi: 10.1016/j.ijcard.2023.131445

It is engineered to have a higher biological potency than native IGF-I or IGF-II and has several advantages over recombinant insulin

PMID: 32545596

Summary of the Interaction Profile | Feature | MK-677 | Vitamin D3 | Combined | |---|---|---|---| | Primary metabolic pathway | CYP3A4 | CYP2R1 / CYP27B1 | No shared pathway conflict | | Effect on serum calcium | Indirect increase via IGF-1/PTH | Direct increase via calcitriol | Additive, monitor | | Effect on bone markers | Increases osteocalcin, ALP | Improves mineralization | Synergistic if D is sufficient | | Insulin sensitivity | Mild decrease at 25 mg/day | May improve in deficient subjects | D correction may partially offset MK-677 effect | | Safety concern | Fasting glucose, fluid retention | Hypercalcemia at very high doses | Low risk at standard doses | | Dose separation needed | No | No | Take together with food acceptable | Frequently asked questions Can I take vitamin D while on MK-677 (Ibutamoren)