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It works by inhibiting melanin production, shifting melanin synthesis from darker eumelanin to lighter pheomelanin, and reducing oxidative stress in skin cells

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It can also be associated with excess alcohol consumption, certain medications, and less commonly, high levels can indicate acute inflammation of the pancreas (pancreatitis)

Weight gain occurs because the treatment (methimazole, thyroidectomy, or radioactive iodine) reduces your thyroid function and turns you hypothyroid, slowing your metabolism

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