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In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability

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This dual potential in responding to both oxidative stress and inflammation may enhance the protective capabilities of FOXO4, making it a potential factor in the cells longevity and resilience

While CLA does present positive outcomes, the changes usually come on slowly and require several months of supplementation

Yu et al, 2017