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Dose increase: at Day 16 inside the on phase, the dose steps from the low end to the high end of the range

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A randomized clinical trial (RCT) demonstrated that high-dose riboflavin supplementation (400 mg/d) could decrease the attack frequency, duration, severity, and number of headache days in adults with migraine, after 3 months

From the second to fifth repeated reactions, the initial reaction rates were lower than those of the sponge

Its often used in medical settings for individuals with severe deficiencies or specific health conditions