10.1016/j.pain.2010.06.019 32 GoldsteinD
While semaglutide pills (like Rybelsus) have existed for years, newer formulations have improved their bioavailability, making them a viable alternative to the traditional semaglutide injection
GLP-1 drugs are being prescribed to millions: an estimated 6 million Americans were on GLP-1 treatment in 2024, with projections reaching 10 million in 2025
However, these observational findings require careful interpretation, as they may be influenced by confounding factors such as overall health status, treatment adherence, healthcare engagement, and indication bias
In one 2024 real-world study, 40% of GLP-1 patients had inadequate protein intake, and 25% had suboptimal vitamin D, B12, iron, or calcium within 3 months of starting therapy
If you miss doses and approach the beyond-use date with significant medication remaining, consult your healthcare provider about whether to continue or obtain a fresh vial, and do not extend use beyond the assigned BUD
