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This review is motivated by the urgent necessity to bridge these fields, addressing the current lack of validated companion diagnostics and structured frameworks to guide the integration of these tools into personalized patient care (Figure 1)

The rational response to genuine uncertainty about an injected substance is caution, not the optimistic assumption that silence in the literature equals a clean bill of health

The protective variant at rs2304256 was shown to decrease STAT1 phosphorylation in B lymphoblastoid cell lines when stimulated with IFN (67)

Physical symptoms often include weakness, pale or jaundiced skin, and a smooth, red tongue that might feel sore