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Successful treatment of severe MSUD in Bckdhb-/- mice with neonatal AAV gene therapy

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The free hormone hypothesis proposes that hormones not bound to carrier proteins with high affinity can freely diffuse across cell membranes to perform their biological activities [13,34]

Some researchers believe that reducing gut inflammation and improving intestinal integrity could indirectly influence mood, cognition, and stress regulation, though this has not been proven clinically