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The evidence base is preclinical with one small human study
Note: Compounded drugs are not approved by the U.S
34,35 However, the controversy surrounding the possible benefits of GIPR agonism stems from two main observations: its impaired insulinotropic effects, 36,37 and the prevention of weight gain by suppression of endogenous GIP-induced adipogenesis, 38,39 However, these seemingly discouraging observations have been questioned by the finding of the central anorexic effects of GIP, 4042 and benefits of the GLP-1R/GIPR dual agonist LY3298176 (tirzepatide) in diabetic and overweight individuals
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[56] The presence of antibodies to gastric parietal cells and intrinsic factor is common in PA
They are not intended for human or animal consumption, and are not to be used for diagnostic, therapeutic, or any clinical purposes
