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TB-500 is commonly discussed as a synthetic fragment related to thymosin beta-4, a naturally occurring peptide involved in cell migration, actin regulation, angiogenesis, and tissue repair signaling

In view of these reported differences in effects of Cannabis sativa as regards depression, the aim of the study was to: (1) examine the effect of cannabis in the forced-swim test (a test for depressive-like behavior) (Porsolt et al., 1978) in normal mice and after treatment with the selective serotonin reuptake inhibitors (SSRIs) fluoxetine and sertraline as well as the tri-cyclic drug imipramine with view to a possible modulatory effect of antidepressant drugs

Sarkar et al., 2019)

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These antioxidants have well-established effects

Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress