GLP-1 exerts several key physiologic effects: Increases glucose-dependent insulin secretion Suppresses inappropriate glucagon release Delays gastric emptying Promotes satiety and reduces appetite Pharmacologic GLP-1 receptor agonists, including semaglutide, liraglutide, and tirzepatide, are engineered to resist DPP-4 degradation, allowing them to persist for hours to days
When GSM is the driver, treatment is highly effective: lubricants and moisturizers help right away, and low-dose vaginal estrogen, prasterone, or ospemifene restore tissue health within 8-12 weeks
While both peptides have been studied for tissue-regenerative properties, they appear to function through different mechanisms: BPC-157 may work primarily through growth factor-mediated pathways and nitric oxide systems
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McGarry, T., Biniecka, M., Veale, D
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