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Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, et al

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191 Once-daily administration of roflumilast significantly improves forced expiratory volume in 1 s and decreases exacerbations, particularly in patients with severe disease, 192,193 but has side effects such as nausea, vomiting and headache