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JAMA Network Open

172 Hence, it seems likely that ghrelin induces glycogenolysis and/or inhibits glucose uptake into peripheral tissues from circulation via direct mechanisms

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Glucose is a substrate for lipogenesis, and either dietary intake of glucose and fructose or hyperglycemia due to T2DM-associated insulin resistance can lead to hepatic de novo lipogenesis

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Moreover, their potential as monotherapy for sequential control of MASLD warrants further investigation