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Patients taking antihypertensives (particularly diuretics, alpha-blockers, or nitrates) or SGLT2 inhibitors may experience additive effects on blood pressure or volume status when starting tirzepatide

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Unlike stimulant medications such as amphetamines or methylphenidate, tirzepatide does not act on the central nervous system's dopaminergic or noradrenergic pathways to increase alertness or blood pressure