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Recent studies have demonstrated that spermidine effectively inhibits the phosphorylation of signal transducer and activator of transcription 1 (STAT1) by upregulating protein tyrosine phosphatase non-receptor 2 (PTPN2), thereby promoting macrophage polarization toward the anti-inflammatory M2 phenotype and suppressing excessive inflammatory responses

Restricting glutamine availability or inhibiting -KG production promotes Foxp3 expression, facilitating the conversion of Th17 cells into Treg-like cells and enhancing Treg differentiation while suppressing Th1/Th17 polarization (113115)

Rice: Iron-fortified rice is becoming more common, especially in countries where rice is a staple food

CIRS requires a structured, phased treatment approach to bring the immune system back into balance