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Therefore, the homocysteine level may not rise enough to the abnormal range in a person with Down syndrome with a decrease in vitamin B12 or folate activity

The evidence for divided dosing over single daily dosing is not established in humans

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Because of these tight temperature constraints, if you live in a regional or remote area where reliable overnight delivery is unavailable, we strongly advise ordering our standard lyophilized (freeze-dried) vials instead, as they are significantly more stable during extended transit times