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doi: 10.2337/diacare.27.11.2628 53 ApovianCMBergenstalRMCuddihyRMQuYLenoxSLewisMSet al

One example is Farxiga (dapagliflozin), a brand-name drug approved to treat Type 2 diabetes and lower the risk of cardiovascular death and hospitalization in people with heart failure (when the heart is weak and cannot pump enough blood)

This is the most commonly used approach, and its strategy is to modify the second N-terminal amino acid position (Ala8) to protect from degradation by DPP-4

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Many patients transition off medication, but maintaining healthy lifestyle habits is essential to avoid regaining weight