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It's a hormonal and metabolic problem

These are animal research doses and cannot be directly translated to human dosing

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Aging, a major risk factor for both conditions [34], is characterized by progressive reductions in skeletal muscle mass and functional capacity [35], beginning around the age of 30 years and potentially resulting in a 3050% loss by 80 years [35]

Next, we estimated and compared the half-maximal inhibitory concentration (IC 50 ) values from the concentrationresponse data using Chinese hamster ovary (CHO K1) cells expressing human TRPV1

Histamine is released in response to all of the triggers listed above