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It is usually temporary

These resolve within 24 to 48 hours for most researchers and can be minimized with the dilution technique mentioned in the dosing section

For obesity as a standalone indication, however, patients must generally fund treatment themselves, with only a limited exception for those with obesity and serious cardiovascular risk

Glucagon receptor effects, particularly the increased energy expenditure and thermogenesis, build gradually as the body adjusts to higher doses

Another limitation is the lack of large-scale, long-term studies in type 1 diabetes

Doctors may also prescribe them to those who are overweightmeaning they have a BMI of 25 to 29.9 and have a health condition, if losing weight can help manage this condition