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It also works outside the brain, what we call in the periphery

PT-141 is a cyclic heptapeptide with a lactam bridge that restricts conformational flexibility, preventing the peptide from adopting the shape required for high-affinity MC1R binding

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[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Geiser J.S., Heathman M.A., Cui X., A Martin J., Loghin C., Chien J.Y., De La Pea A

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The PlexusDx Precision Peptide Genetic Test analyzes GLP1R (rs6923761), GIPR (rs1800437), and MC4R (rs17782313) variants that relate to GLP-1 and related signaling pathways