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While erastin (an inhibitor of the cystineglutamate antiporter system Xc) was senolytic in SK-MEL-103 cells and BSO (a sulfoximine derivative that reduces levels of glutathione) in IMR90 cells, only the three GPX4 inhibitors tested showed senolytic activity in all senescent models tested (Extended Data Fig

Wolff V, Schlagowski A-I, Rouyer O, Charles A-L, Singh F, Auger C, et al

doi:10.1007/s00441-019-03016-8 Ilic S, Drmic D, Franjic S, et al

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J Med Genet

They found significantly increased cord blood MDA levels in samples obtained during spray seasons and increased fetal DNA fragmentation, indicating enhanced fetal OS