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At 26 weeks after treatment, the weight loss was -2.29 0.24 kg for 1.5 mg DUL, -1.36 0.24 kg for 0.75 mg DUL, and -2.22 0.24 kg for metformin (110)

In reality, how therapy is reduced or discontinued can significantly influence long-term outcomes especially the risk of rebound weight gain

Our study extends beyond the work of Xie and colleagues by examining an even broader range of clinical outcomes (up to 1,026 phenotypes) while leveraging electronic health record (EHR) data from the All of Us Research program (AOU), 65 a nationally recruited EHR-linked biobank specifically designed to oversample groups historically underrepresented in biomedical research