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53 Furthermore, elevated cholesterol levels in the microenvironment stimulate the expression of immune checkpoints, including PD-1, 2B4, TIM-3, and LAG-3, in T cells, driving T-cell exhaustion via the activation of the endoplasmic reticulum stress response

The limitations of oral glutathione include absorption challenges and mild adverse effects

Figure 2 Although environmental determinants of male infertility originate from diverse sources including airborne particulates, heavy metals, endocrine-disrupting chemicals, microplastics, and temperature changes they cannot be an isolated threat (21)

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These are not serious and may be minimised with proper use and guidance

Estes, C., Razavi, H., Loomba, R., Younossi, Z