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Meaningful changes in body composition, energy, and recovery develop over 3 to 6 months of consistent use

The bioavailability of most commercially-available products is problematic, and some have not been tested in children

The transdermal composition of claim 2 which provides at least one of the following release pattern in an In Vitro study employing dialysis membrane and a phosphate buffer of pH 7.4 i) at least 30 % release in 24 hrs and 70 % release in 72 hrs

Several pieces of scientific evidence support this

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