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2.4.6 PI3K/AKT and Sirtuin1 The autophagy-lysosomal pathway is responsible for maintaining the metabolic balance of the ECM by sequestering FN within the cytosol and activating lysosomes for degradation in fibrosis (Guo et al., 2020)

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A free access to solid normal diet (Altromin 1324, Genestil, Royaucourt, France) was allowed from day 3