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This gap between preclinical promise and human clinical validation is the defining characteristic of the current pipeline

An association between the presence of TDP-43 in the spinal cord and CTE cases with a progressive motor neuron disease, amyotrophic lateral sclerosis (ALS), is evidence that repetitive head trauma might be linked to impairments in the motor system

Moreover, although statistically insignificant, extrathyroidal tumor extension, which is known to be associated with poor prognosis in PTC, showed a non-significant positive correlation with GLP-1R expression in PTC in our study

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However, these effects are typically small and inconsistent across studies, and the mechanisms remain poorly understood