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If the 24-week trial could not demonstrate significant weight loss, there is no reason to believe that longer use would produce dramatically different results

In order to evaluate the mechanisms of action of tirzipatide, in a recent study [62] subjects with T2DM performed a deep metabolic evaluation with measures of beta cell function and insulin sensitivity by hyperglycemic clamp, mixed meal test and euglycemic clamp before and 28 weeks after treatment with tirzepatide 15 mg or semaglutide 1 mg

Laird, A.M

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