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Neuropsychiatric disorders: predominance of astrocytic atrophy and loss of function Mood disorders Major depressive disorder (MDD) Decreases in the total number of glial cells and astrocytes are the main and most consistent histopathological hallmark of MDD post-mortem brains
Zhu X, et al
103 The specific parameters can be based on patient-centered shared decision-making, considering each persons stage and severity of disease, risk of progression, and comorbidities
Extended-release exenatide (Bydureon BCise), given weekly, uses a microsphere suspension that may cause more injection site nodules (reported in 10.5% of patients according to its FDA label) compared to solution-based formulations
Furthermore, enhanced permeability of the blood-brain barrier is a critical neurovascular complication of T2DM, which disrupts CNS homeostasis and impairs its function
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