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91 These compensatory pathways act in concert to blunt the efficacy of singleagent Gln inhibitors, highlighting the need for combination strategies that simultaneously target ASNS and FAO to overcome metabolic plasticity

In the microenvironment of acute gout, where UA and H 2 O 2 levels are elevated, the nano-Pt in PDA@Pt not only catalyzes the degradation of UA through its uricase activity but also decomposes H 2 O 2 through its CAT activity, producing oxygen (O 2 ) and alleviating cellular hypoxia

In this method Free and Total GSH are measured in the same well, with only one sample required for both results

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