Science 319 , 16401642 (2008)
Die orale Applikation liefert hohe lokale Konzentrationen im Magen-Darm-Trakt, erreicht aber nur eine geringe systemische Bioverfgbarkeit, da Peptide im Verdauungstrakt teilweise abgebaut werden
SOD activity in diabetes is reduced due to the glycation of the enzyme, which leads to an accumulation of superoxide radicals and oxidative stress
Fatty acid oxidation (FAO) is used by M2 macrophages to support many tasks, such as proliferation, by supplying energy for oxidative phosphorylation and electron transfer via the TCA cycle [76]
There are three isoforms of NOS, each transcribed by separate genes
In addition, there are several other stress kinases that were found to regulate NRF2 nuclear localization by phosphorylation, including the ER stress kinase PERK and the energy sensor AMPK [13, 14]