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Combining both medications addresses blood sugar control from multiple angles metformin reduces liver glucose production while Ozempic promotes insulin secretion and suppresses appetite

Instructing the patient to administer the evening NPH insulin dose at bedtime rather than before dinner helps prevent insulin waning and ensures better glycemic control upon waking

Abstract Background Tirzepatide, a once-weekly glucose-dependent insulinotropic polypeptide/ glucagon-like peptide-1 receptor agonist, is approved in the United States, Europe and Japan for the treatment of type 2 diabetes

The meta-analytic finding on weight regain describes an average trajectory across study populations