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Next, the clinical landscape and principal limitations of current therapeutics are summarized, enabling the identification of critical unresolved issues

Immune dysfunction

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Accessed February 18, 2026

DNA fiber assay To investigate how the DNA-binding affinity of PDS5B affects replication fork protection, plasmids expressing PDS5B (WT) or PDS5B (17 A), as well as control or PDS5B-targeting siRNAs, were transfected using FuGENE HD (Promega) and Lipofectamine RNAiMAX (Invitrogen), respectively, according to the manufacturers instructions

If these are full, there are two public car parks just a 2-minute walk from the clinic: Castle Yard Car Park Swan Street Car Park Both are located on Swan Street.