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LC-MS/MS separation of endocrine disrupting compounds (EDCs) was performed using a 50 mm 2.1 mm (id), 1.8 m particle (dia) Titan C18 reversed-phase UHPLC column (Supelco, Bellefonte, PA) in combination with a guard column equipped with a guard column insert containing C18 stationary phase complementary with the analytical column

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943 NG/EDA is triggered by the acidic and edaravone-induced high levels of GSH microenvironment, enabling selective and sustained release of edaravone at the site of ischemic injury to enhance its neuroprotective effects

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Because melasma involves multiple triggers, it is often considered a complex pigment disorder rather than a simple discoloration

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