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Read the full article here: To view or add a comment, sign in A major challenge in hematologic malignancies is understanding how variability in drug exposure influences both efficacy and safety to support optimized dose selection and regulatory decision making
Both preclinical and clinical studies show that circadian disruption aggravates BBB injury, characterized by reduced expression of tight junction proteins (ZO-1, occludin, claudin-5), heightened neuroinflammation (TNF-, IL-1), MMP-9/2mediated extracellular matrix degradation, and HPA axis dysregulation
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10.1183/09031936.00026910 87 HillD
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