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One such adaptation she and her colleagues have been studying is an increase in the amount of the enzyme glutamine synthetase, which makes glutamine from other starting materials, namely glucose

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This effect was not sensitive to naloxone, indicating a distinct mechanism from its opioid-mediated antinociceptive effects 8

Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes

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