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Theres also the possibility of insulin resistancethe bodys lowered ability to regulate blood sugarwhich comes with its own metabolic risk factors, like kidney disease and type 2 diabetes

In addition, loss of podocytes, either due to apoptosis and/or podocyte detachment from the glomerular basement membrane, was shown to be an early event in the development of diabetic nephropathy in humans and various animal models of diabetic nephropathy [196,197,198]

10.1038/s41585-023-00764-9 89 ScheidE.MajorP.BergeronA.FinnO

Sun, 2019), which accounts for the permeability of the membrane to different ions and their respective intracellular and extracellular concentrations

Understanding this helps contextualize the temporary worsening some researchers experience