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Free histones (H2A/H3) initiate the activation of NF-B/p38 MAPK via the TLR2/4-MyD88 pathway, thereby triggering a cascade of pro-inflammatory cytokines (e.g., IL-6, TNF-), platelet aggregation, and activation of coagulation factor XII
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paired t test) versus +0.7 1.3 fibers/mm 2 for placebo (n = 19
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It is believed that increasing PQQ concentrations may lead to a burst of reactive oxygen species (ROS), a reduction in ATP production, disruption of mitochondrial membrane potential (MMP), decreased production of the cytoprotective Bcl-2 protein, activation of caspase-3, and irregular MAPK phosphorylation patterns (Min et al., 2014b)
