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In peripheral tissues, GIP receptor activation in adipocytes promotes lipid storage under fed conditions but may facilitate lipolysis when insulin levels are low, a nuanced effect that remains an active area of investigation in metabolic research [5]

For example, if you started semaglutide in 2024 with a BMI of 37 and your BMI has since dropped to 32, you still qualify

placebo in patients with poor weight loss following metabolic surgery: the BARI-OPTIMISE randomized clinical trial

[6] [7] They work by mimicking the action of a naturally occurring hormone called GLP-1, which is released from the intestines after eating