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Steuerman R, Shevah O, Laron Z: Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies

Taken together this shows that although there are demonstrated signaling pathways in the communication between GM and the host and that this may include appetite control, the overall effect on whole animals is not fully understood

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Furthermore, enhancer factor 2 (EF2) acts as a downstream effector within the TGF-1 pathway and plays an essential role in HSC activation and the progression of fibrosis