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And so if I'm treating someone 65 years old, 70 years old for obesity and obesity-related complications, I am concerned about how much weight they're going to lose, because part of it will be muscle and they're not going to be able to build it back likely

[29] Those two novel peptides were later isolated, identified, and investigated by other researchers, and are now known as glucagon-like peptide-1 and glucagon-like peptide-2

Starting low and escalating gradually produced fewer gastrointestinal side effects than starting directly at a higher dose, which is why the 2mg +2mg-every-4-weeks schedule became the standard escalation approach in the published data