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That said, "generally safe" does not mean "universally safe for everyone in all circumstances." Individual reactions vary

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References Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, et al

Tirzepatide: Key Warnings, Risks, and Considerations for Use Warnings include: Possible pancreatitis Hypoglycemia, when combined with insulin or insulin secretagogues Can cause hypersensitivity reactions Acute kidney injury from dehydration Potential worsening of diabetic retinopathy Gallbladder disease and gastroparesis-related concerns remain relevant

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