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That edges out tirzepatides 20.2% and semaglutides 13.7% from the head-to-head SURMOUNT-5 trial because each drug adds one more hormone receptor to the target list

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Abbreviations GLP-1 RA: Glucagon-like peptide-1 receptor agonist MACE: Major adverse cardiovascular events HR: Hazard ratio CI: Confidence interval HER: Electronic health record ICD: International statistical classification of diseases and related health statistical classification of diseases and related health problems CPT: Current procedural terminology BMI: Body mass index MRA: Mineralocorticoid receptor antagonist ACE inhibitor: Angiotensin converting enzyme inhibitor ARB: Angiotensin II receptor blocker SGLT2 inhibitor: Sodium-glucose co-transporter 2 GFR: Glomerular filtration rate HbA1c: Hemoglobin A1c STROBE: Strengthening the reporting of observational studies in epidemiology SD: Standard deviation PS: Propensity score SMD: Standardized mean difference References Nichols, G

More studies are clearly needed

It may help the body lose fat by reducing appetite, improving fullness, supporting blood sugar control, and making it easier to maintain a calorie deficit

Rome: FAO and WHO