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Data analysed by two-way repeated measures ANOVA to assess main effects of treatment ( b and c )

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In skeletal muscle cells, SELENOW was shown to reduce the binding of 14-3-3 to a transcriptional co-activator with PDZ-binding motif (TAZ) (23), allowing TAZ translocation to the nucleus and subsequent activation of muscle cell differentiation genes (24)

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73 In patients with reflux-predominant symptoms unresponsive to lifestyle modification, proton pump inhibitors or histamine-2 receptor antagonists may be used

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