2014;2:e429
Priority Review designation is possible given the magnitude of the trial results, which could shorten this timeline to 6 months
Heterogeneous stain-ing of GPX1 in beta cells is consistent with recent obser-vations that demonstrate asynchronous destruction of beta cells during T1D (Thompson et al
Coffee might help some, but it could also make others worse, like jitteriness
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Although these results hint at potential beyond-weight reproductive benefits (83), the extremely small sample size ( n = 28), open-label design, and lack of objective measurements for key biological intermediates (e.g., oocyte/embryo quality and endometrial receptivity), combined with controversies over the adequacy of the washout period, mean these conclusions should be viewed as exploratory rather than definitive