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Abstract Background Obesity is one of the critical public health problems in our society

Over time, this persistent inflammatory state damages tissues, impairs organ function, and even erodes cognitive health, setting the stage for age-related diseases such as diabetes, cardiovascular disease, neurodegeneration, and cancer

Modern clinic-grade presentation

Importantly, targeting of MK-801 to GLP-1 receptor-expressing brain regions circumvents adverse physiological and behavioural effects associated with MK-801 monotherapy

Federal health regulators will want to see more complete data on safety, tolerability and effectiveness before considering the pills for possible approval.