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It is also worth noting that long-term use of H1 and H2 blocking medications, such as the commonly used antihistamines Telfast, Zyrtec, and Claratyne for H1 blockade, or Pepcid and Tagamet for H2 blockade while providing short-term symptom relief, can potentially worsen histamine intolerance over time by affecting the gut environment and DAO enzyme function, making nutritional and root-cause approaches to management particularly important