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Fact: Stopping GLP-1 medications suddenly may contribute to increased appetite and rapid weight regain, so its important to work with a healthcare provider on a transition plan

Update on FDAs ongoing evaluation of reports of suicidal thoughts or actions in patients taking a certain type of medicines approved for type 2 diabetes and obesity 2024 Available from: Ruggiero R, Mascolo A, Spezzaferri A, Carpentieri C, Torella D, Sportiello L, et al

Cureus , doi: 10.7759/cureus.77998 (2025)

This requires urgent medical assessment

These trials, including STEP-1 through STEP-6, highlighted semaglutides superiority over placebo and other treatments, such as liraglutide, in promoting weight loss and enhancing cardiometabolic parameters, including blood pressure and lipid profiles [6][15]

Further studies may reveal is other medications like topical or oral metformin can have benefit as well