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For adults with obesity or weightrelated comorbidities, the pipeline is moving faster than the care models built to receive it

When you swallow an oral supplement, the active compounds have to survive stomach acid, get absorbed through the intestinal wall, and pass through the liver's first-pass metabolism before reaching systemic circulation

The STEP 1 clinical trial, which investigated the efficacy of 2.4 mg semaglutide, included a substudy specifically analyzing body composition via dual-energy X-ray absorptiometry (DEXA) [1]

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Participants had an average A1C reduction of up to 2.0% and lost an average of 36.6 pounds

doi: 10.1126/scitranslmed.3007218 45 OduoriOSMuraoNShimomuraKTakahashiHZhangQDouHet al