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Changes in SPARC level in our study were correlated with changes in circulating levels of decorin, which is a collagen-associated extracellular matrix proteoglycan that promotes the formation of bone matrix and calcium deposition to regulate bone morphogenesis [26]

As most oral Vitamin C doses above 250mg are very poorly absorbed, the only efficacious high dose oral delivery system is via liposomes from natural phosphatidyl choline

This can cause weight gain and fatigue

(Menopause definitely counts as a time of stress!) Epidemiological studies have shown higher vitamin C plasma concentrations in women, suggesting that women may need more of it than men , and low concentrations in both sexes have been associated with symptoms of aging, including cognitive decline

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