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40 , 41 , 42 , 43 , 44 In a 14month crossover study of women with PCOS and hirsutism ( n = 16), metformin reduced weight and hair growth and improved cycle frequency compared with placebo, with no change in sex hormone binding globulin (SHBG) and free androgen index (FAI)

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In alignment with our immunohistochemical results, at P16 the density of SynTom-labeled inputs was 37.4% higher in the PVHmpd of GCG-Cre::SynTom::Lep ob/ob mice, and 33.8% higher in the PVHpml, compared with GCG-Cre::SynTom::WT mice (Figure 3AC